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Moreover, the indole core is substituted at R3 with a carbonyl group and that is also bonded into a napthalene moeity. Napthalene can be a bicyclic composition of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it for a ketone. JWH-018 can be an analog of THJ-018, through which the core indazole framework is substituted with the